Huperzine A
Huperzine A is a compound from the herb Huperzia serrata that may inhibit the breakdown of acetylcholine. Its use in sports is still under-researched.
Clinical dosage
Origin
NaturalHuperzine A is extracted from the Chinese club moss Huperzia serrata, also known as toothed clubmoss. It has been used for centuries in traditional Chinese medicine (Qian Ceng Ta). In supplements as purified extract.
Safety
Huperzine A is an acetylcholinesterase inhibitor and must be dosed with respect. Doses of 50-200mcg per day are used in studies. Side effects at higher doses include nausea, diarrhea, and muscle twitching. Don't combine with anticholinergics or cholinesterase inhibitors.
For comparison
Huperzine A works similarly to Alzheimer's medications (like donepezil), but at much lower doses. It inhibits the breakdown of acetylcholine, making more available for your brain. The dose in pre-workouts (50-200mcg) is tiny compared to pharmaceutical agents.
Dosage by weight and gender
The typical huperzine A dose is 50-200mcg per day (note: micrograms, not milligrams). Body weight plays a limited role. There are no gender-specific recommendations. Cycling (4 weeks on, 1 week off) is often recommended due to the long half-life. Don't use daily for extended periods without breaks.
Frequently asked questions
What does huperzine A do?▼
Huperzine A may improve mental focus and memory by inhibiting the breakdown of acetylcholine. In pre-workouts it's added for a sharper mind-muscle connection. Sun et al. (1999) found improvements in memory and learning ability in young students.
Is huperzine A dangerous?▼
At the low doses in pre-workouts (50-200mcg) the risk is limited. However, it's an active compound affecting acetylcholine levels. Don't combine with other cholinergic agents. Take breaks with long-term use and consult a doctor if you use medications.
How much huperzine A per day?▼
50-200mcg (micrograms) per day. Most pre-workouts contain 100-200mcg. Take it cyclically: 4 weeks on, 1 week off. The half-life is long (10-14 hours), so it accumulates with daily use.
Scientific sources
The clinical dosages on this page are based on peer-reviewed research.
- Huperzine A: a promising drug for Alzheimer's diseaseWang R, Tang XC — Acta Pharmacol Sin (2005)
Pre-workouts with Huperzine A
No products found with this ingredient