Collagen type II
Undenatured type II collagen from chicken cartilage, given as 40 mg per day in every trial.
What the research shows
Mixed or small evidence. The effect is uncertain.
Lugo (2016) saw better WOMAC scores than placebo in knee osteoarthritis after 180 days, in a study where two of three authors worked for the brand owner. Schön (2022) reported greater pain-free knee flexion, run by a contract research organisation for the producer. Kumar (2023) could pool only a handful of trials and called the evidence limited.
Who it makes sense for: People with mild knee osteoarthritis still having symptoms after standard care who want to try it themselves.
How we weigh evidenceClinical dosage
Scientific sources
The clinical dosages on this page are based on peer-reviewed research.
- Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.Lugo JP et al. (2016)Funded by: Twee van de drie auteurs zijn werknemer van InterHealth Nutraceuticals, eigenaar van het UC-II-merk; studie door de fabrikant gefinancierd.
- UC-II Undenatured Type II Collagen for Knee Joint Flexibility: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study.Schön C et al. (2022)Funded by: Meerdere auteurs zijn werknemer van Lonza Greenwood LLC, producent van UC-II; uitgevoerd door contractonderzoeksbureau BioTeSys.
- Efficacy of undenatured collagen in knee osteoarthritis: review of the literature with limited meta-analysis.Kumar P et al. (2023)
We keep the dosages and values on this page as accurate as possible based on selected studies. New research may change these values. Nothing on this page is medical advice. If you have any doubts, always consult a doctor.