MSM (methylsulfonylmethane)
Sulfur compound taken as a powder or capsule for joint complaints.
What the research shows
Mixed or small evidence. The effect is uncertain.
Brien (2008) found positive but small and short studies and drew no conclusion. Debbi (2011) saw a modest improvement in pain and function in a few dozen patients with knee osteoarthritis. Toguchi (2023) reported slightly better quality of life in mild knee pain, with an author from a supplement manufacturer on the research team.
Who it makes sense for: People with mild knee osteoarthritis who want to test for themselves whether it does anything.
How we weigh evidenceClinical dosage
Scientific sources
The clinical dosages on this page are based on peer-reviewed research.
- Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis.Brien S et al. (2008)
- Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study.Debbi EM et al. (2011)
- Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.Toguchi A et al. (2023)
We keep the dosages and values on this page as accurate as possible based on selected studies. New research may change these values. Nothing on this page is medical advice. If you have any doubts, always consult a doctor.