Synephrine
Synephrine comes from bitter orange and is often used to support fat burning. It can also have a mild stimulant effect.
Clinical dosage
Origin
NaturalSynephrine naturally occurs in bitter orange (Citrus aurantium), also known as Seville orange. It's found in the peel and traditionally used in Chinese medicine as zhi shi.
Safety
Synephrine (p-synephrine) increases metabolism and fat burning. At doses up to 50mg per day, no significant effects on heart rate or blood pressure have been found (Stohs et al., 2012). Don't combine with other stimulants at high doses.
For comparison
A bitter orange contains about 6mg of synephrine. A pre-workout with 30mg synephrine equals about 5 bitter oranges. The metabolic effect is comparable to a strong cup of green tea.
Dosage by weight and gender
The effective synephrine dose is 20-50mg per day for fat burning and energy (Stohs et al., 2012). Body weight plays a limited role. Start with a low dose (20mg) and build up. No significant differences between men and women have been reported.
Frequently asked questions
What does synephrine do?▼
Synephrine activates beta-3 adrenergic receptors, increasing metabolism and fat burning. It works as a milder, more targeted version of ephedrine. It can also improve energy performance during training.
Is synephrine dangerous?▼
At the recommended dose (20-50mg), synephrine is safe for healthy adults. A review by Stohs et al. (2012) confirms p-synephrine doesn't significantly raise heart rate or blood pressure. Don't combine it with large amounts of caffeine or other stimulants.
How much synephrine per day?▼
20-50mg per day, preferably split into 2-3 doses. Take it 30 minutes before training or between meals. Don't exceed 50mg per day, especially if you also use caffeine.
Scientific sources
The clinical dosages on this page are based on peer-reviewed research.
- p-Synephrine alone and in combination with selected bioflavonoids: metabolic effects and safetyStohs SJ et al. — Int J Med Sci (2012)
Pre-workouts with Synephrine
No products found with this ingredient