Nitrosigine
Nitrosigine is a patented form of arginine bonded to silicate. It boosts nitric oxide production and can improve blood flow and muscle pump.
Clinical dosage
Origin
SyntheticNitrosigine (inositol-stabilized arginine silicate) is a patented ingredient by Nutrition21. It's a synthetic complex of arginine, silicate, and inositol designed to make arginine more stable and bioavailable than regular L-arginine.
Safety
Nitrosigine has been clinically studied and found safe at the standard dose of 1,500mg per day. It raises arginine blood levels more effectively than regular arginine. No significant side effects reported in clinical studies (Kalman et al., 2015).
For comparison
1,500mg of Nitrosigine raises your arginine blood levels comparably to 8g of citrulline malate, but in a much smaller dose. The effect also lasts longer, up to 6 hours after intake versus 1-2 hours with regular arginine.
Dosage by weight and gender
The clinically studied Nitrosigine dose is 1,500mg per session (Kalman et al., 2015). Body weight doesn't play a significant role in dosing. No gender-specific differences are known. The effect starts after a single dose and builds with daily use over 14 days.
Frequently asked questions
What is Nitrosigine?▼
Nitrosigine is a patented form of arginine that's better absorbed than regular L-arginine. It's bound to silicate and stabilized with inositol, keeping it active in your blood longer. Clinical studies show it increases NO production and blood flow.
Is Nitrosigine better than citrulline?▼
Both have their advantages. Nitrosigine works at a smaller dose (1.5g vs 6-8g citrulline) and the effect lasts longer. Citrulline has a longer research history and is cheaper. The best pre-workouts sometimes combine both.
How much Nitrosigine per day?▼
The clinical dose is 1,500mg (1.5g) per day, preferably 30 minutes before training. This is the dose used in virtually all studies. Taking more doesn't provide additional benefits.
Scientific sources
The clinical dosages on this page are based on peer-reviewed research.
- Inositol-stabilized arginine silicate (ASI; Nitrosigine) for improved vasodilation and exercise performanceKalman D et al. — J Int Soc Sports Nutr (2015)
Pre-workouts with Nitrosigine
No products found with this ingredient